Deconstructing Kidney Development and Repair for Therapeutic Opportunity
Guest Speaker: Andrew McMahon, PhD, FRS
University of Southern California Provost Professor and Keck Professor Director of the Eli and Edythe Broad-CIRM Center
Thursday October 26, 2023, Broad 100
A joint Merkin Institute / Beckman Institute Sponsored Seminar
Faculty Hosts: Barbara Wold & Marianne Bronner
Function follows form. For the kidney, patterning of tubular epithelial networks, arising from distinct cellular progenitors, and an organ-wide alignment of functional domains, underpins body fluid homeostasis. Kidney injury invokes repair responses with maladaptive outcomes. The CDC estimates 1 in 7 US adults have chronic kidney disease. In light of clinical need, our group has two broad interests: fully understanding and replicating human kidney development to better engineer kidney replacement and generate authentic disease models; and, improving renal injury outcomes through a mechanistic understanding of endogenous repair processes.