The focus of Professor Mayo's lab has been the coupling of theoretical, computational, and experimental approaches for the study of structural biology. They have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy they call "protein design automation." Their design approach has been captured in a suite of software programs called ORBIT (Optimization of Rotamers By Iterative Techniques) which has been applied to a variety of problems ranging from protein fold stabilization to enzyme design. See more at The Mayo Laboratory website.
